BPS Pharmacotherapy (Part1 and Part2) : BPS-Pharmacotherapy

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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A 72-year-old man has chronic insomnia that has not responded to measures to improve sleep hygiene. The patient is not depressed and has no other chronic health problems. It is determined that medication use will probably be necessary to manage the insomnia. What is the best initial recommendation for this patient?

A) Trazodone
B) Amitriptyline
C) Alprazolam
D) Diphenhydramine

2. A study shows that the participants who received 6 months of a new oral anticoagulant after a venous thromboembolism were randomized to continue with the new oral anticoagulant (n =
612) or to placebo (n = 611) for 18 months. Thromboembolism recurred in 12 subjects in the new oral anticoagulant group and 71 subjects in the placebo group (hazard ratio 0.17; 95% CI, 0.09-
0.30; p < 0.001).
Which of the following statements regarding these results is correct?

A) The difference between the new oral anticoagulant and placebo in the secondary prevention of venous thromboembolism is not statistically significant.
B) The new oral anticoagulant reduces the relative risk of a secondary venous thromboembolism by 17% compared to placebo.
C) The new oral anticoagulant reduces the relative risk of a secondary venous thromboembolism by 9.6% compared to placebo.
D) The new oral anticoagulant reduces the relative risk of a secondary venous thromboembolism by 83% compared to placebo.

3. A population study of gentamicin pharmacokinetics in 425 neonates reported the following correlation by least-squares linear regression between gestational age and gentamicin clearance:
r2 = 0.35, p = 0.0001. Which of the following is the most appropriate interpretation of these data?

A) A significant correlation exists between gestational age and gentamicin clearance, with gestational age accounting for 65% of the variability in gentamicin clearance.
B) A correlation coefficient of less than 0.8 essentially means no significant relationship exists between gestational age and gentamicin clearance in neonates.
C) A significant correlation exists between gestational age and gentamicin clearance, with gestational age accounting for 59% of the variability of gentamicin clearance.
D) A significant correlation exists between gestational age of newborns and gentamicin clearance, but gestational age accounts for only 35% of the variability in clearance.

4. A 70-year-old 45-kg patient is admitted to the ICU with a diagnosis of digoxin intoxication. The patient complains of nausea, blurred vision, and fatigue that have been present for 3 days. A cardiac monitor reveals a HR of 42 bpm, an irregular rhythm, and a type second-degree heart block. Current medications include digoxin 0.25 mg and furosemide 40mg for heart failure, both taken daily at 0800. The patient remains adherent to all medications despite nausea, including today's doses. Blood is drawn at 1200 with the following results:
* Potassium: 6.0 mEq/L
* Creatinine: 2.3 mg/dL
* Digoxin: 1.7 ng/mL
Which of the following most appropriately describes the patient's digoxin concentration?

A) A pre-distribution digoxin concentration, which may be misinterpreted
B) A concentration within the desirable range
C) A post-distribution digoxin concentration, which indicates significant toxicity
D) Reflects the effect of furosemide on the renal excretion of digoxin

5. A 58-year-old man recently diagnosed with chronic stable angina has discontinued metoprolol due to erectile dysfunction. Medical history also includes hypertension and type 2 diabetes mellitus. The patient's current medications include aspirin, lisinopril, metformin, and sublingual nitroglycerin as needed. BP is 128/76 mm Hg, and HR 88 bpm.
Which of the following is the most appropriate choice to manage the patient's stable angina symptoms?

A) Atenolol
B) Amlodipine
C) Diltiazem CD
D) Vardenafil

Solutions: